In silico identification of functional LC3 Interacting Region Motifs

Experimentally validated LIR-motif containing proteins, taken from Alemu et al., 2012, analysed by iLIR. The * symbol indicates proteins which were also included in Behrends et al., 2010 (see below).

ATG13_HUMAN ATG19_YEAST ATG1_YEAST ATG32_YEAST ATG3_YEAST
ATG4B_HUMAN* BNI3L_HUMAN CALR_HUMAN CBL_HUMAN CLH1_HUMAN
DVL2_HUMAN FUND1_HUMAN FYCO1_HUMAN* NBR1_HUMAN OPTN_HUMAN
Q8MQJ7_DROME Q9SB64_ARATH RBCC1_HUMAN SQSTM_HUMAN* STBD1_HUMAN*
T53I1_HUMAN T53I2_HUMAN TBC25_HUMAN TBCD5_HUMAN ULK1_HUMAN
ULK2_HUMAN

Additional experimentally validated LIR-motif containing proteins, taken from Birgisdottir, Lamark and Johansen, 2013, analyzed by iLIR.

ATG34_YEAST C0H519_PLAF7 BNIP3_HUMAN CACO2_HUMAN CTNB1_HUMAN
MK15_HUMAN TAXB1_HUMAN

Human proteins tested for LIR-dependent interactions with GABARAP and MAP1LC3B, taken from Behrends et al., 2010, analyzed by iLIR.

STK4_HUMAN STK3_HUMAN RASF5_HUMAN NEDD4_HUMAN A16L1_HUMAN
TFCP2_HUMAN SF3A1_HUMAN FNBP1_HUMAN TBC15_HUMAN ANFY1_HUMAN
TCPR2_HUMAN ECHA_HUMAN NIPS2_HUMAN ATG5_HUMAN ATG7_HUMAN
KPCI_HUMAN EPN4_HUMAN ATG3_HUMAN DYXC1_HUMAN NEK9_HUMAN
UBA5_HUMAN TBD2B_HUMAN KBTB6_HUMAN IPO5_HUMAN NCOA7_HUMAN
KAP0_HUMAN GYS1_HUMAN KBTB7_HUMAN ATG2A_HUMAN FAN_HUMAN