iLIR v1.0 WWW Server: RESULTS PAGE

Submitted 1 sequence
>sp|P46934|NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 OS=Homo sapiens GN=NEDD4 PE=1 SV=4

{"length":"1319","regions":[{
startStyle: "straight", endStyle: "straight",
start: 152, end: 171, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 152, end: 171}
},
{
startStyle: "straight", endStyle: "straight",
start: 270, end: 283, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 270, end: 283}
},
{
startStyle: "curved", endStyle: "curved",
start: 611, end: 643, text: "WW", colour: "#ff8800",
"metadata":{ database: "SMART", type: "WW",
description: "WW", start: 611, end: 643}
},
{
startStyle: "straight", endStyle: "straight",
start: 728, end: 747, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 728, end: 747}
},
{
startStyle: "curved", endStyle: "curved",
start: 768, end: 800, text: "WW", colour: "#ff8800",
"metadata":{ database: "SMART", type: "WW",
description: "WW", start: 768, end: 800}
},
{
startStyle: "straight", endStyle: "straight",
start: 810, end: 825, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 810, end: 825}
},
{
startStyle: "curved", endStyle: "curved",
start: 841, end: 873, text: "WW", colour: "#ff8800",
"metadata":{ database: "SMART", type: "WW",
description: "WW", start: 841, end: 873}
},
{
startStyle: "curved", endStyle: "curved",
start: 893, end: 925, text: "WW", colour: "#ff8800",
"metadata":{ database: "SMART", type: "WW",
description: "WW", start: 893, end: 925}
},
{
startStyle: "curved", endStyle: "curved",
start: 982, end: 1318, text: "HECTc", colour: "#ff8800",
"metadata":{ database: "SMART", type: "HECTc",
description: "HECTc", start: 982, end: 1318}
},
{
startStyle: "straight", endStyle: "straight",
start: 410, end: 415, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:SEYIKL", start: 410, end: 415}
},
{
startStyle: "straight", endStyle: "straight",
start: 589, end: 594, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:PGWVVL", start: 589, end: 594}
},
{
startStyle: "straight", endStyle: "straight",
start: 1296, end: 1301, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:ESFEEL", start: 1296, end: 1301}
},
]
}

xLIR motifs are displayed as magenta rectangles in the domain architecture graphic

MOTIF	START	END	LIR sequence	PSSM score	In PDB	Anchor
xLIR	410	415	SEYIKL	13 (7.9e-02)		No
xLIR	589	594	PGWVVL	19 (1.2e-02)	3M7F_B	Yes
xLIR	1296	1301	ESFEEL	13 (7.9e-02)	[+/-] 2XBF_A 2XBB_A,B 2XBF_A 2XBB_A,B 3TUG_A 1ZVD_A 1ND7_A 3H1D_A 3G1N_A,B 1D5F_A,B,C 1C4Z_A,B,C 4BBN_A 4BE8_A 3JVZ_C,D 3JW0_C,D 2ONI_A 4LCD_A,B 3OLM_A	No

[+/-] Show/Hide Detailed ANCHOR results

DOMAIN	START	END	STATUS
ANCHOR01	1	12	hidden
ANCHOR02	30	37	hidden
ANCHOR03	116	123	hidden
ANCHOR04	243	250	hidden
ANCHOR05	260	269	hidden
ANCHOR06	285	290	hidden
ANCHOR07	319	327	hidden
ANCHOR08	456	469	hidden
ANCHOR09	484	489	hidden
ANCHOR10	521	530	hidden
ANCHOR11	543	551	hidden
ANCHOR12	560	570	hidden
ANCHOR13	588	604	hidden
ANCHOR14	620	631	hidden
ANCHOR15	650	666	hidden
ANCHOR16	685	702	hidden
ANCHOR17	711	733	hidden
ANCHOR18	746	769	hidden
ANCHOR19	781	790	hidden
ANCHOR20	799	810	hidden
ANCHOR21	835	862	hidden
ANCHOR22	873	880	hidden
ANCHOR23	907	914	hidden

[+/-] Show/Hide Detailed SMART results

DOMAIN	START	END	E-VALUE	TYPE	STATUS
low_complexity_region	152	171	0	INTRINSIC	visible\|OK
low_complexity_region	270	283	0	INTRINSIC	visible\|OK
low_complexity_region	603	614	0	INTRINSIC	hidden\|overlap
SMART:WW	611	643	1.9e-13	SMART	visible\|OK
Pfam:WW	612	641	8.5e-16	PFAM	hidden\|overlap
internal_repeat_1	615	641	1.0e-07	PROSPERO	hidden\|overlap
low_complexity_region	728	747	0	INTRINSIC	visible\|OK
SMART:WW	768	800	1.5e-12	SMART	visible\|OK
Pfam:WW	769	798	2.2e-14	PFAM	hidden\|overlap
low_complexity_region	810	825	0	INTRINSIC	visible\|OK
SMART:WW	841	873	9.3e-13	SMART	visible\|OK
Pfam:WW	842	871	1.4e-15	PFAM	hidden\|overlap
SMART:WW	893	925	9.6e-15	SMART	visible\|OK
Pfam:WW	894	923	2.7e-16	PFAM	hidden\|overlap
internal_repeat_1	897	923	1.0e-07	PROSPERO	hidden\|overlap
SMART:HECTc	982	1318	4.1e-193	SMART	visible\|OK
Pfam:HECT	1013	1318	6.3e-97	PFAM	hidden\|overlap